Login | Register

Gel Alternative To Contraceptive Pill Shows Promising Results In Small Trial

A gel alternative to the contraceptive pill that women may only have to rub into the skin every day to prevent ovulation has shown promising results in a small phase 2 clinical trial reported at a conference in the US this week.

The birth control gel, which the trial investigators referred to as Nestorone®-Estradiol (NES/E2), is being developed by the drug firm Antares Pharma Inc, with corporate offices in New Jersey, in partnership with the not-for-profit Population Council research center in New York, both in the US.

Dr. Ruth Merkatz, director of clinical development of reproductive health at the Population Council presented the findings of the trial in an oral session of the 66th Annual Meeting of the American Society for Reproductive Medicine (ASRM) in Denver, Colorado, on Monday.

According to information on the Antares website, Nesterone is a “pipeline product” currently completing Phase 2 trials and about to enter Phase 3.

The NES/E2 transdermal gel, which is is rubbed into the skin of the arms, thighs, shoulders or abdomen, contains two hormones, a potent progestin close to progesterone, and natural estrogen (Estradiol), and has the same effect as the combined oral pill, but without causing weight gain, nausea and reduced sexual desire.

For the study, the researchers recruited 18 healthy ovulating women in their 20s and 30s in Chile, the Dominican Republic and the US. Over 7 months, the women tested three doses of NES/E2: a high dose (4.5mg Nesterone NES and 1.5 mg Estradiol E2), a medium (3.0 mg NES, 1.0 mg E2), and a low (1.5 mg NES, 0.5 mg E2).

The results showed that the medium dose demonstrated “good ovarian suppression” and the researchers selected it for further study.

There was also minimal breakthrough bleeding during 3 weeks of use, and the participants reported that the gel was easy to use and remember, and had few side effects. Their partners also reported no negative effects.

Merkatz and colleagues concluded that NES/E2 showed “promising results and may represent a safe, effective, acceptable hormonal method of contraception”.

They said more studies in larger groups should now be done.

The idea of a gel is thought to be more appealing to women than a skin patch, which can fall off and is visible.

Family planning experts said that while it is still early days, they welcomed the news because it gives women more choice.


One Response to “Gel Alternative To Contraceptive Pill Shows Promising Results In Small Trial”

  • […] October 26, 2010: Gel Alternative To Contraceptive Pill Shows Promising Results In Small Trial October 25, 2010: Potentially Deadly Superbug Rising In Chicago Hospitals October 25, 2010: Paralyzed Man Brain Damaged After Nurse Accidentally Switches Off His Life Support, UK October 24, 2010: Malaria-Transmitting Mosquito Evolving, NIH Grantees Find October 24, 2010: Research Shows a Phone Call can Improve Diabetic Condition October 23, 2010: Too Many Sisters Affect Male Sexuality October 23, 2010: The Impact Of Chronic Diseases On Patients Also Depends On Their Perception Of The Disease October 23, 2010: Researchers Develop First Implanted Device To Treat Balance Disorder October 22, 2010: Low-Dose Aspirin May Cut Risk Of Developing And Dying From Colon Cancer October 21, 2010: Superior Sedation Method For Children Revealed By Study October 21, 2010: Miniature Solar Cells Might Make Chemotherapy Less Toxic October 21, 2010: Malaria Much Bigger Killer In India Than We Thought October 19, 2010: Real-Time Non-Invasive Blood Monitor Could Cut Transfusions During Surgery October 17, 2010: Need A Study Break To Refresh? Maybe Not, Say Stanford Researchers October 17, 2010: New Research Helps Clinicians Predict Treatment Outcomes For Children With OCD October 16, 2010: Melanin Production Controlled By Molecular Switch, May Allow True Sunless Tanning October 15, 2010: Lay Bystanders Should Do Just Chest Compressions, No Mouth-To-Mouth October 14, 2010: Link Between Vegetable Consumption And Decreased Breast Cancer Risk In African-American Women October 14, 2010: Age-Related Memory Loss In Mice Reversed By Promising Drug Candidate October 12, 2010: Higher Kidney Stone Risk For Postmenopausal Women On Estrogen Therapy October 11, 2010: Common Prostate Cancer Treatment Linked To Bone Decay October 10, 2010: Discovery Could Impact How The Body Receives Medicine October 10, 2010: Thoughts About Time Inspire People To Socialize October 8, 2010: Insoluble Medicines Can Be Made Orally Available If In Nano Crystal October 7, 2010: Hidden In Your Genes There May Be A Thirst For Excitement October 7, 2010: AACN Applauds The New Institute Of Medicine Report Calling For Transformational Change In Nursing Education And Practice October 5, 2010: Human Growth Hormone Shows Promise In Treating Cystic Fibrosis Symptoms October 5, 2010: Researchers Identify First Ever Treatment Effective Against Terminal Cancer In Animals October 1, 2010: 12 Percent Of Workers Would Choose To Quit Or Retire Rather Than Report For Work During A Serious Pandemic […]

Leave a Reply

Your email address will not be published. Required fields are marked *